Article

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Skeletal muscle atrophy occurs in several diseases and is associated with chronic stress. Studies indicate that glucocorticoid receptor signalling is the major signalling pathway that mediates stress-induced muscle degeneration. Although the glucocorticoid signalling pathway is relatively well characterized, there is a need to identify modulators of this pathway that may be useful for drug targe...

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Literature Corpus work: 7ef7afe1-ffe9-58ea-825e-b95305ba7612
DOI: 10.1101/2025.10.22.683887

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