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Article

SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.

Circulation - 21 Nov 2017

Tang Xiaoqiang, Chen Xiao-Feng, Wang Nan-Yu, Wang Xiao-Man, Liang Shu-Ting, Zheng Wei, Lu Yun-Biao, Zhao Xiang, Hao De-Long, Zhang Zhu-Qin, Zou Ming-Hui, Liu De-Pei, Chen Hou-Zao

Abstract excerpt

BACKGROUND: Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to investigate the roles of SIRT2 in aging-related and angiotensin II (Ang II)-induced...

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Identifiers

PMID: 28947430
DOI: 10.1161/CIRCULATIONAHA.117.028728
PMCID: PMC5698109

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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