Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy

13 Sept 2017

Abstract excerpt

Muscle wasting, also known as cachexia, is associated with many chronic diseases, which worsens prognosis of primary illness leading to enhanced mortality. Molecular basis of this metabolic syndrome is not yet completely understood. SIRT6 is a chromatin-bound member of the sirtuin family, implicated in regulating many cellular processes, ranging from metabolism, DNA repair to aging. SIRT6 knockout (SIRT6-KO) mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Muscle Physiology and Disorders
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28928419
DOI: 10.1038/s41598-017-10838-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophyPMID 28928419Read ↗

Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative DiseaseSemantic proximity Read ↗

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in miceSemantic proximity Read ↗

Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expressionSemantic proximity Read ↗

The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitusSemantic proximity Read ↗

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunSemantic proximity Read ↗

SirT1 in muscle physiology and disease: lessons from mouse modelsSemantic proximity Read ↗

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesitySemantic proximity Read ↗

The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem CellsSemantic proximity Read ↗

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Semantic proximity Read ↗

Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signalingSemantic proximity Read ↗

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activitySemantic proximity Read ↗

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.