Back to search

Article

Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species

2022-04-18

Abstract excerpt

<h4>Background</h4> There are seven sirtuin genes in the mammalian genome. Each sirtuin gene contains multiple exons, and is likely to undergo alternative splicing, thereby increasing sirtuin gene diversity. Since the alternatively spliced isoforms tend to increase with advancing age, it is important to study the effect of sequence change on isoform function. Additionally, the divergence of isoform patterns betwe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b9f54d4b-ae5d-541c-aed3-d365db00a62c
DOI
10.1101/2022.04.18.488659
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across speciesDOI 10.1101/2022.04.18.488659
Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function.Semantic proximity
The sirtuin family in health and diseaseSemantic proximity
Recent progress in the biology and physiology of sirtuinsSemantic proximity
SIRT1: recent lessons from mouse modelsSemantic proximity
The human sirtuin family: Evolutionary divergences and functionsSemantic proximity
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related ConditionsSemantic proximity
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family MemberSemantic proximity
A New Splice Variant of the Mouse SIRT3 Gene Encodes the Mitochondrial Precursor ProteinSemantic proximity
Interaction between SIRT1 and non-coding RNAs in different disordersSemantic proximity
The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitusSemantic proximity
Bioinformatic analysis of SIRT7 sequence and structureSemantic proximity
The sirtuin family’s role in aging and age-associated pathologiesSemantic proximity
Select a neighboring publication to make it the new centre.