Article

GRK5 is an Essential Co-repressor for Cardiac Mineralocorticoid Receptor Antagonism induced by Finerenone but not Eplerenone

2020-09-17

Abstract excerpt

<h4>Background: </h4> In the heart, aldosterone (Aldo) binds the mineralocorticoid receptor (MR) to exert damaging, adverse remodeling-promoting effects. We recently showed that G protein-coupled receptor (GPCR)-kinase (GRK)-5 blocks the cardiac MR by directly phosphorylating it, thereby repressing its transcriptional activity. MR antagonist (MRA) drugs block the cardiac MR reducing morbidity and mortality of adva...

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Literature Corpus work: 7ed9f73e-f0ad-5f42-8564-c72dbf2ea102
DOI: 10.20944/preprints202009.0374.v1

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