Article
Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.
BMC genetics - 27 Feb 2012
Nolan Daniel K, Sutton Beth, Haynes Carol, Johnson Jessica, Sebek Jacqueline, Dowdy Elaine, Crosslin David, Crossman David, Sketch Michael H, Granger Christopher B, Seo David, Goldschmidt-Clermont Pascal, Kraus William E, Gregory Simon G, Hauser Elizabeth R, Shah Svati H
Abstract excerpt
BACKGROUND: Coronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although the genetic architecture is incompletely defined. We previously reported a linkage peak on chromosome 5q31-33 for early-onset CAD where the strength of evidence for linkage was increased in families with higher mean low density lipoprotein-cholesterol (LDL-C)....
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