Article
An integrative investigation on significant mutations and their down-stream pathways in lung squamous cell carcinoma reveals CUL3/KEAP1/NRF2 relevant subtypes.
Molecular medicine (Cambridge, Mass.) - 20 May 2020
Liu Zongang, Deng Meiyan, Wu Lin, Zhang Suning
Abstract excerpt
BACKGROUND: Molecular mechanism of lung squamous cell carcinoma (LUSC) remains poorly understood, hampering effective targeted therapies or precision diagnosis about LUSC. We devised an integrative framework to investigate on the molecular patterns of LUSC by systematically mining the genomic, transcriptional and clinical information. METHODS: We utilized the genomics and transcriptomics data for the LUSC cohorts...
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