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A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma

4 Apr 2025

Abstract excerpt

Tractable, patient-relevant models are needed to investigate cancer progression and heterogeneity. Here, we report an alternative in vitro model of lung squamous cell carcinoma (LUSC) using primary human bronchial epithelial cells (hBECs) from three healthy donors. The co-operation of ubiquitous alterations (TP53 and CDKN2A loss) and components of commonly deregulated pathways including squamous differentiation...

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PMID: 40185723
DOI: 10.1038/s41467-025-58343-y

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