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Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory Epilepsy

2023-10-05

Abstract excerpt

Temporal lobe epilepsy (TLE) is a type of focal epilepsy characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis of epileptogenesis suggests that the development of TLE is associated with alterations in gene transcription changes resulting in a hyperexcitable network in TLE. DNA 5-methylcytosine (5-mC) is an epigenetic mechanism that has been associ...

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Literature Corpus work
7e6f5d2d-dfd6-5bbb-83f0-8c9aae05baba
DOI
10.1101/2023.10.03.560698
Open publication

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Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory EpilepsyDOI 10.1101/2023.10.03.560698
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