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Article

Divergent prion strain evolution driven by PrPC expression level in transgenic mice.

Nature communications - 23 Jan 2017

Le Dur Annick, Laï Thanh Lan, Stinnakre Marie-George, Laisné Aude, Chenais Nathalie, Rakotobe Sabine, Passet Bruno, Reine Fabienne, Soulier Solange, Herzog Laetitia, Tilly Gaëlle, Rézaei Human, Béringue Vincent, Vilotte Jean-Luc, Laude Hubert

Abstract excerpt

Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrPC into PrPSc. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Constrained interactions between PrPC and different PrPSc strains can in turn lead to certain PrPSc (sub)populations being selected for cross-species transmission, or even...

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Identifiers

PMID: 28112164
DOI: 10.1038/ncomms14170
PMCID: PMC5264111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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