Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD

Abstract excerpt

BACKGROUND: The evolution of the variant Creutzfeldt-Jakob disease (vCJD) epidemic is hazardous to predict due to uncertainty in ascertaining the prevalence of infection and because the disease might remain asymptomatic or produce an alternate, sporadic-like phenotype. METHODOLOGY/PRINCIPAL FINDINGS: Transgenic mice were produced that overexpress human prion protein with methionine at codon 129, the only allele...

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