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Article

A multimeric assembly factor controls the formation of alternative 20S proteasomes.

Nature structural & molecular biology - 1 Mar 2008

Kusmierczyk Andrew R, Kunjappu Mary J, Funakoshi Minoru, Hochstrasser Mark

Abstract excerpt

The proteasome is the central regulatory protease of eukaryotic cells. Heteroheptameric alpha-subunit and beta-subunit rings stack to form the 20S proteasome, which associates with a 19S regulatory particle (RP). Here we show that two yeast proteins, Pba3 and Pba4, form a previously unidentified 20S proteasome-assembly chaperone. Pba3-Pba4 interacts genetically and physically with specific proteasomal alpha...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18278055
DOI: 10.1038/nsmb.1389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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