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Article

Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation.

Biochemical and biophysical research communications - 25 Jul 2014

Takagi Kenji, Saeki Yasushi, Yashiroda Hideki, Yagi Hirokazu, Kaiho Ai, Murata Shigeo, Yamane Takashi, Tanaka Keiji, Mizushima Tsunehiro, Kato Koichi

Abstract excerpt

Eukaryotic proteasome assembly is assisted by multiple dedicated chaperones. In yeast, formation of the heteroheptameric ring composed of α1-α7 subunits is promoted by the heterodimeric chaperone Pba3-Pba4. Here we reveal that in the absence of this dimeric chaperone, α2 replaces α4 during α-ring assembly, thereby giving rise to a non-productive complex that lacks α4, β1, β5, β6, and β7 subunits and aggregates of...

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Identifiers

PMID: 24996173
DOI: 10.1016/j.bbrc.2014.06.119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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