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An unexpected lack of difference in superoxide/H <sub>2</sub> O <sub>2</sub> production rates in isolated heart and skeletal muscle mitochondria from a mouse model of Barth Syndrome

2020-05-08

Abstract excerpt

Barth Syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial superoxide/H 2 O 2 production has been implicated in the cardiomyopathy observed in different BTHS models. There are at least 11 mitochondrial sites that produce superoxide/H 2 O 2 at significant rates. Which of these sites generate oxidants...

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Literature Corpus work
7dfe2901-d649-5d55-9134-c7334403010f
DOI
10.1101/2020.05.07.083105
Open publication

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