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Article

Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome.

Journal of molecular and cellular cardiology - 1 Aug 2018

Johnson Jordan M, Ferrara Patrick J, Verkerke Anthony R P, Coleman Chanel B, Wentzler Edward J, Neufer P Darrell, Kew Kimberly A, de Castro Brás Lisandra E, Funai Katsuhiko

Abstract excerpt

Barth Syndrome (BTHS) is an X-linked recessive disorder characterized by cardiomyopathy and muscle weakness. The underlying cause of BTHS is a mutation in the tafazzin (TAZ) gene, a key enzyme of cardiolipin biosynthesis. The lack of CL arising from loss of TAZ function results in destabilization of the electron transport system, promoting oxidative stress that is thought to contribute to development of...

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Identifiers

PMID: 30008435
DOI: 10.1016/j.yjmcc.2018.07.001
PMCID: PMC6178222

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MCAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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