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Article

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.

Free radical biology & medicine - 1 Apr 2009

Chinta Shankar J, Rane Anand, Yadava Nagendra, Andersen Julie K, Nicholls David G, Polster Brian M

Abstract excerpt

Apoptosis-inducing factor (AIF)-deficient harlequin (Hq) mice undergo neurodegeneration associated with a 40-50% reduction in complex I level and activity. We tested the hypothesis that AIF and complex I regulate reactive oxygen species (ROS) production by brain mitochondria. Isolated Hq brain mi...

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Source

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Identifiers

PMID: 19280713
DOI: 10.1016/j.freeradbiomed.2009.01.010
PMCID: PMC2775507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19280713-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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