Article

Sex-dependent neuronal loss and apoptosis-associated signaling in the anterior cingulate and anterior insular cortices in a late-stage MIA mouse model of osteoarthritis

2026-02-11

Abstract excerpt

Osteoarthritis (OA) is a leading cause of disability worldwide, with chronic pain representing its most debilitating symptom and frequently accompanied by affective and cognitive comorbidities. Increasing evidence implicates maladaptive supraspinal plasticity within cortical regions involved in pain affect, including the anterior cingulate cortex (ACC) and anterior insular cortex (AIC), however, the relationship b...

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Literature Corpus work: 7ddfcbea-cf2e-5bcd-a8a0-4e92566e15a0
DOI: 10.64898/2026.02.09.704883

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