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Article

CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo.

Science (New York, N.Y.) - 24 Aug 2007

Konev Alexander Y, Tribus Martin, Park Sung Yeon, Podhraski Valerie, Lim Chin Yan, Emelyanov Alexander V, Vershilova Elena, Pirrotta Vincenzo, Kadonaga James T, Lusser Alexandra, Fyodorov Dmitry V

Abstract excerpt

The organization of chromatin affects all aspects of nuclear DNA metabolism in eukaryotes. H3.3 is an evolutionarily conserved histone variant and a key substrate for replication-independent chromatin assembly. Elimination of chromatin remodeling factor CHD1 in Drosophila embryos abolishes incorporation of H3.3 into the male pronucleus, renders the paternal genome unable to participate in zygotic mitoses, and...

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Share to Chromatin Assembly and Disassembly
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17717186
DOI: 10.1126/science.1145339
PMCID: PMC3014568

Genes

CHD1
HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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