Article

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression

2023-11-19

Abstract excerpt

Despite well-documented metabolic and hematopoietic alterations during tumor development 1 , the mechanisms underlying this crucial immunometabolic intersection have remained elusive. Of particular interest is the ligand-activated transcription factor retinoic acid-related orphan receptor 1 (RORC1/RORγ), whose activity is boosted by cholesterol metabolites 2 , acting as a modulator of cancer-related emergency my...

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Literature Corpus work: 7dbf7804-36c8-51f3-87cc-bbc825db7cd4
DOI: 10.1101/2023.11.19.567414

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