Article
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk.
Annals of neurology - 1 Oct 2026
Peña-Tauber Andrés, Hernández Arriaza Ricardo, Reil Dylan, Muntaner Manon, Park Junyoung, Grenier-Boley Benjamin, Hulsman Marc, Amouyel Philippe, Bellenguez Céline, Charbonnier Camille, Deleuze Jean-François, Dols-Icardo Orio, Hardy John, Holstege Henne, Nicolas Gaël, Mead Simon, Wagner Michael, Ramirez Alfredo, Sims Rebecca, van Swieten John, Willams Julie, Lambert Jean-Charles, Khosla Chaitan, Le Guen Yann, Greicius Michael D
Abstract excerpt
OBJECTIVE: ATP-binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation. We explored whether genetic variants altering ABCA1 function interact with APOE isoforms to modify AD risk. METHODS: Using data from the Alzheimer's Disease...
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- Humans
- ATP Binding Cassette Transporter 1
- Alzheimer Disease