Article

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

2022-04-30

Abstract excerpt

Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line. PALLD is ubiquitously expressed in several isoforms and its longest 200 kDa isoform, predominantly expressed in striated muscle, shows high structural homology to MYPN. MYPN gene mutations are associated with human cardiomyopathies, whereas the role of PALLD in...

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Literature Corpus work: 7db1ace9-4982-5865-87cf-99cc0ff6b296
DOI: 10.1101/2022.04.29.489866

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