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Article

Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2021

de Lange Willem J, Farrell Emily T, Kreitzer Caroline R, Jacobs Derek R, Lang Di, Glukhov Alexey V, Ralphe J Carter

Abstract excerpt

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may provide an important bridge between animal models and the intact human myocardium. Fulfilling this potential is hampered by their relative immaturity, leading to poor physiological responsiveness. hiPSC-CMs grown in traditional two-dimensional (2D) culture lack a t-tubular system, have only rudimentary intracellular calcium-handling...

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Identifiers

PMID: 33606581
DOI: 10.1152/ajpheart.00941.2020
PMCID: PMC8260387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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