Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery

31 Mar 2022

Abstract excerpt

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased donors have the potential to recapitulate the molecular and functional features of the human heart. Although the immaturity of hiPSC-CMs, including the structure, gene expression, conduct, ion channel density, and Ca 2+ kinetics, is a major challenge,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroscience and Neural Engineering
Share to Pluripotent Stem Cells Research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35433691
DOI: 10.3389/fcell.2022.855763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Engineered Heart Tissue Models for Disease Modeling and Drug DiscoveryPMID 35433691Read ↗

Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D CulturesSemantic proximity Read ↗

Cardiac tissue engineering: Multiple approaches and potential applicationsSemantic proximity Read ↗

Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes.Semantic proximity Read ↗

From engineered heart tissue to cardiac organoidSemantic proximity Read ↗

Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug DiscoverySemantic proximity Read ↗

Human Induced Pluripotent Stem Cells as a Disease Model System for Heart FailureSemantic proximity Read ↗

Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes.Semantic proximity Read ↗

Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult MyocardiumSemantic proximity Read ↗

The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic DiseasesSemantic proximity Read ↗

Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screeningSemantic proximity Read ↗

Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.