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Article

Screen for ISG15-crossreactive Deubiquitinases

25 Jul 2007

Abstract excerpt

BACKGROUND: The family of ubiquitin-like molecules (UbLs) comprises several members, each of which has sequence, structural, or functional similarity to ubiquitin. ISG15 is a homolog of ubiquitin in vertebrates and is strongly upregulated following induction by type I interferon. ISG15 can be covalently attached to proteins, analogous to ubiquitination and with actual support of ubiquitin conjugating factors....

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PMID: 17653289
DOI: 10.1371/journal.pone.0000679

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