Article

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

2018-09-26

Abstract excerpt

Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization and employment of a vertebrate ‘insulin-free’ model to identify insulin-independent modulators of glucose metabolism. insulin knockout zebrafish recapitulate core characteristics of diabetes and survive only up to larval stages. Util...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6b883b2-eb55-54c8-815c-69a63d1f7203
DOI: 10.1101/427831

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonistsDOI 10.1101/427831Read

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonistsSemantic proximity Read

Beyond drug discovery: Exploring the physiological and methodological dimensions of zebrafish in diabetes researchSemantic proximity Read

Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyondSemantic proximity Read

Transgenic and Knockout Mice in Diabetes Research: Novel Insights into Pathophysiology, Limitations, and PerspectivesSemantic proximity Read

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiationSemantic proximity Read

Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetesSemantic proximity Read

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.Semantic proximity Read

Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic miceSemantic proximity Read

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of DiabetesSemantic proximity Read

Animal Models for Understanding the Mechanisms of Beta Cell Death during Type 2 Diabetes PathogenesisSemantic proximity Read

Non-Genetic-Induced Zebrafish Model for Type 2 Diabetes with Emphasis on Tools in Model ValidationSemantic proximity Read

Tissue‐specific insulin signaling in the regulation of metabolism and agingSemantic proximity Read