Article

A prioritized medium-throughput screen identifies FGF4, FGF5, FGF8F, FGF19 and FGF21 as protective factors for human stem cell derived insulin secreting beta cells

2025-02-16

Abstract excerpt

<h4> Abstract </h4> Stem cell-derived β-like cells (SCβ cells) are a potential alternative to cadaveric β cells for replacement therapy in type 1 diabetes. However, SCβ cells face a multitude of stresses that must be overcome. Both β cells and SCβ cells reside in complex microtissues and can therefore be modulated by hundreds of autocrine/paracrine signals within these islets or spheroids. Here, we leveraged mul...

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Literature Corpus work: dc45e2c0-d210-520d-9387-ea01156fcf40
DOI: 10.1101/2025.02.12.637990

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