Article

LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression

2022-03-06

Abstract excerpt

Lysyl-oxidase like-2 (LOXL2) regulates extracellular matrix remodeling and promotes tumor invasion and metastasis. Altered metabolism is a core hallmark of cancer, however, it remains unclear whether and how LOXL2 contributes to tumor metabolism. Here, we found that LOXL2 and its catalytically inactive L2Δ13 splice variant also function as novel deacetylases that trigger metabolic reprogramming during malignant tr...

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Literature Corpus work: 7d857256-52ce-5948-83b2-f84cf2ab8b67
DOI: 10.1101/2022.03.06.483165

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