Article

Blood transcriptomic analysis reveals novel hub gene pathways associated with serum galactose-deficient IgA1 level in IgA nephropathy

2024-10-14

Abstract excerpt

<title>Abstract</title> <p>Background We sought to identify the differentially expressed genes (DEG) and biological pathways in blood B cells involved in the production of galactose-deficient IgA1 (Gd-IgA1) levels in IgA nephropathy (IgAN). Methods Deep sequencing on RNA isolated from B cells was used for microarray validation. The relationship between target mRNA expressions and Gd-IgA1 levels in serum were al...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d5f065d-cfc5-5e8b-8a01-7ca828847947
DOI: 10.21203/rs.3.rs-4875709/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Blood transcriptomic analysis reveals novel hub gene pathways associated with serum galactose-deficient IgA1 level in IgA nephropathyDOI 10.21203/rs.3.rs-4875709/v1Read

Integrative Transcriptomic Analysis Implicates Platelet Activation as a Potential Pathological Mechanism in IgA Nephropathy: Evidence from Multi-Dataset Analysis and Urinary Biomarker ValidationSemantic proximity Read

Increased APRIL Expression Induces IgA1 Aberrant Glycosylation in IgA NephropathySemantic proximity Read

Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease.Semantic proximity Read

Single-Cell RNA-Sequencing Data Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of IgA NephropathySemantic proximity Read

Identifying Therapeutic Strategies in IgA Nephropathy through Comprehensive Transcriptomic CharacterizationSemantic proximity Read

C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin A nephropathySemantic proximity Read

Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA NephropathySemantic proximity Read

Screening and Bioinformatics Analysis of IgA Nephropathy Gene Based on GEO DatabasesSemantic proximity Read

Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets.Semantic proximity Read

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.Semantic proximity Read

Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.Semantic proximity Read

GWAS for serum galactose-deficient IgA1 implicates critical genes of the <i>O</i> -glycosylation pathwaySemantic proximity Read