Article

Integrative Transcriptomic Analysis Implicates Platelet Activation as a Potential Pathological Mechanism in IgA Nephropathy: Evidence from Multi-Dataset Analysis and Urinary Biomarker Validation

2026-04-06

Abstract excerpt

<title>Abstract</title> <p>Background Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease globally. Although platelet activation has been implicated in IgAN progression, comprehensive transcriptomic evidence and validated urinary biomarkers reflecting this process are lacking. This study aimed to identify platelet activation as a key pathological mechanism through integrative ana...

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Literature Corpus work: 34cfcb61-61b5-59a4-9177-0449ed103310
DOI: 10.21203/rs.3.rs-9234090/v1

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