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Increased APRIL Expression Induces IgA1 Aberrant Glycosylation in IgA Nephropathy

1 Mar 2016

Abstract excerpt

Aberrant glycosylated IgA1 molecules, mainly galactose-deficient IgA1 (Gd-IgA1), are important causal factors in IgA nephropathy; however, the underlying mechanism for the production of aberrantly glycosylated IgA1 is unknown. A recent genome-wide association study identified a novel IgAN susceptibility gene, TNFSF13, which encoded a proliferation-inducing ligand (APRIL) that promotes lymphocyte proliferation and...

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PMID: 26986150
DOI: 10.1097/md.0000000000003099

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