Article

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

2024-07-02

Abstract excerpt

Head and Neck Squamous Cell Carcinoma (HNSCC) remains a significant health burden due to tumor heterogeneity and treatment resistance, emphasizing the need for improved biological understanding and tailored therapies. This study enrolled 31 HNSCC patients for the establishment of patient-derived tumor organoids (PDOs), which faithfully maintained genomic features and histopathological traits of primary tumors. Lon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e124931-1ca9-539e-863e-bbcffd2b7686
DOI: 10.1101/2024.06.28.601068

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinomaDOI 10.1101/2024.06.28.601068Read

Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell CarcinomaSemantic proximity Read

PATIENT-DERIVED ORGANOIDS CAPTURE HISTOLOGICAL, MOLECULAR AND THERAPEUTIC HETEROGENEITY IN PHARYNGEAL AND LARYNGEAL SQUAMOUS CELL CARCINOMASSemantic proximity Read

Predicting Head and Neck Squamous Cell Carcinoma outcomes using long-term Patient-Derived Tumor OrganoidsSemantic proximity Read

Head and neck cancer patient-derived tumouroid cultures: opportunities and challengesSemantic proximity Read

Clonal spheroids capture functional and genetic heterogeneity of head and neck cancerSemantic proximity Read

Integrative Single-Cell and Bulk Transcriptomes Analyses Identify Intrinsic HNSCC Subtypes with Distinct Prognoses and Therapeutic VulnerabilitiesSemantic proximity Read

Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck CancerSemantic proximity Read

Unravelling the Complexity of HNSCC through Single-Cell TranscriptomicsSemantic proximity Read

Patient-derived urachal cancer organoids for personalized drug screeningSemantic proximity Read

Unravelling the heterogeneity of oral squamous cell carcinoma by integrative analysis of single‐cell and bulk transcriptome dataSemantic proximity Read

Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses.Semantic proximity Read

Head and Neck Tumor Organoid Grown under Simplified Media Conditions Model Tumor Biology and Chemoradiation ResponsesSemantic proximity Read