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Article

Exploring New Dimensions of Tumor Heterogeneity: The Application of Single Cell Analysis to Organoid-Based 3D In Vitro Models.

Advanced healthcare materials - 1 Oct 2023

Landon-Brace Natalie, Li Nancy T, McGuigan Alison P

Abstract excerpt

Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to investigating fundamental cancer biology and developing novel treatment strategies that holistically address the factors affecting tumor progression and therapeutic response. Thus, the development of new tools for both in vitro modeling, such as patient-derived organoids (PDOs) and complex 3D in vitro models, and single cell...

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Identifiers

PMID: 37589373
DOI: 10.1002/adhm.202300903
PMCID: PMC11468421

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