Article

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

2024-01-12

Abstract excerpt

As the primary Ca 2+ release channel in skeletal muscle sarcoplasmic reticulum (SR), mutations in the type 1 ryanodine receptor (RyR1) or its binding partners underlie a constellation of muscle disorders, including malignant hyperthermia (MH). In patients with MH mutations, exposure to triggering drugs such as the halogenated volatile anesthetics biases RyR1 to an open state, resulting in uncontrolled Ca 2+ rele...

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Literature Corpus work: 7d46a151-121c-5007-9fd8-69e3aa2a4312
DOI: 10.1101/2024.01.10.575040

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