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Article

Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors.

Molecular pharmacology - 1 Feb 2018

Shin Daniel J, Germann Allison L, Johnson Alexander D, Forman Stuart A, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

GABAA receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have identified two binding domains through which propofol acts on the GABAA receptor. These domains are defined by the β(M286) residue at the β"+"-α"-" interface in the transmembrane region and the β(Y143) residue near the β"-" surface in the junction between the...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29192122
DOI: 10.1124/mol.117.110403
PMCID: PMC5772375

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