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Article

Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation.

BioMed research international - 1 Jan 2021

Watanabe Tomoyuki, Miyoshi Hirotsugu, Noda Yuko, Narasaki Soshi, Morio Atsushi, Toyota Yukari, Kimura Hiroshi, Mukaida Keiko, Yasuda Toshimichi, Tsutsumi Yasuo M

Abstract excerpt

BACKGROUND: We investigated the potential safety of remimazolam and propofol in malignant hyperthermia- (HM-) susceptible patients using ryanodine receptor 1- (RYR1-) expressing human embryonic kidney- (HEK-) 293 cells. METHODS: We compared the enhanced responsiveness of HEK-293 cells expressing wild-type RYR1 with that of mutant RYR1 to caffeine following perfusion with remimazolam or propofol. Furthermore, we...

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Identifiers

PMID: 33490280
DOI: 10.1155/2021/8845129
PMCID: PMC7801102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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