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Article

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.

Structure (London, England : 1993) - 6 Feb 2025

Iyer Kavita A, Kobayashi Takuya, Murayama Takashi, Samsó Montserrat

Abstract excerpt

Mutations in the skeletal isoform of the ryanodine receptor 1 (RyR1) pose grave risks during anesthesia or treatment with succinylcholine muscle relaxants. These can trigger a potentially lethal malignant hyperthermia (MH) episode via intracellular calcium increase mainly from RyR1 channel leakage. Dantrolene is the only known treatment option to prevent death. The main target of dantrolene is RyR1; however,...

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Identifiers

PMID: 39708816
DOI: 10.1016/j.str.2024.11.018
PMCID: PMC11805659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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