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Article

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

The Journal of biological chemistry - 25 Jul 2008

Jiang Dawei, Chen Wenqian, Xiao Jianmin, Wang Ruiwu, Kong Huihui, Jones Peter P, Zhang Lin, Fruen Bradley, Chen S R Wayne

Abstract excerpt

Naturally occurring mutations in the skeletal muscle Ca(2+) release channel/ryanodine receptor RyR1 are linked to malignant hyperthermia (MH), a life-threatening complication of general anesthesia. Although it has long been recognized that MH results from uncontrolled or spontaneous Ca(2+) release from the sarcoplasmic reticulum, how MH RyR1 mutations render the sarcoplasmic reticulum susceptible to volatile...

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Identifiers

PMID: 18505726
DOI: 10.1074/jbc.M801944200
PMCID: PMC2475718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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