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Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS

2023-02-21

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting an extremely complex pathogenic landscape. This heterogeneity has limited the identification of an effective therapy, and this bleak prognosis will on...

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Literature Corpus work
7d387f00-0454-5208-adbf-1d7764d8c499
DOI
10.21203/rs.3.rs-2598728/v1
Open publication

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