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Article

Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord.

The FEBS journal - 1 Jun 2009

Zhai Jianjun, Ström Anna-Lena, Kilty Renee, Venkatakrishnan Priya, White James, Everson William V, Smart Eric J, Zhu Haining

Abstract excerpt

Familial amyotrophic lateral sclerosis (ALS) has been linked to mutations in the copper/zinc superoxide dismutase (SOD1) gene. The mutant SOD1 protein exhibits a toxic gain-of-function that adversely affects the function of neurons. However, the mechanism by which mutant SOD1 initiates ALS is unclear. Lipid rafts are specialized microdomains of the plasma membrane that act as platforms for the organization and...

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Source

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Identifiers

PMID: 19438725
DOI: 10.1111/j.1742-4658.2009.07057.x
PMCID: PMC2754564

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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