Article

Lamin A upregulation reorganizes the genome during rod photoreceptor degeneration

2023-02-08

Abstract excerpt

<title>Abstract</title> <p>Neurodegenerative diseases are accompanied by dynamic changes in gene expression, including the upregulation of hallmark stress-responsive genes. While the transcriptional pathways that impart adaptive and maladaptive gene expression signatures have been the focus of intense study, the role of higher order nuclear organization in this process is less clear. Here, we examine the role of...

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Literature Corpus work: 2e10680f-d520-542f-b972-fbec446ef81b
DOI: 10.21203/rs.3.rs-2518916/v1

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