Article
A widespread decrease of chromatin accessibility in age-related macular degeneration
2018-02-13
Abstract excerpt
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. The extent to which epigenetic changes regulate AMD progression is unclear. Here we globally profiled chromatin accessibility in the retina and retinal pigmented epithelium (RPE) from AMD patients and controls. Global decreases in chromatin accessibility occurr in RPE in early AMD, and in the retina with advanced disease, sugges...
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Identifiers and source
- Literature Corpus work
- a0a8be95-918d-558a-9164-409cb8f9858e
- DOI
- 10.1101/264564