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Histone deficiency and hypoacetylation in the aging retinal pigment epithelium

26 Feb 2024

Abstract excerpt

Histones serve as a major carrier of epigenetic information in the form of post-translational modifications which are vital for controlling gene expression, maintaining cell identity, and ensuring proper cellular function. Loss of histones in the aging genome can drastically impact the epigenetic landscape of the cell leading to altered chromatin structure and changes in gene expression profiles. In this study,...

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PMID: 38408164
DOI: 10.1111/acel.14108

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