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ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

4 Apr 2018

Abstract excerpt

Age-related macular degeneration (AMD) is a significant cause of vision loss in the elderly. The extent to which epigenetic changes regulate AMD progression is unclear. Here we globally profile chromatin accessibility using ATAC-Seq in the retina and retinal pigmented epithelium (RPE) from AMD and control patients. Global decreases in chromatin accessibility occur in the RPE with early AMD, and in the retina of...

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PMID: 29636475
DOI: 10.1038/s41467-018-03856-y

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