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Disrupted Sleep-Dependent Neural Oscillations and Transcriptomic Changes in the <i>Cacna1g</i> Loss-of-Function Mouse Model Implicated in Schizophrenia

2026-02-07

Abstract excerpt

Sleep is an essential biological process for maintaining brain function, and impaired sleep microarchitecture is a well-established feature of schizophrenia (SCZ). Rare loss-of-function variants in CACNA1G , encoding the T-type calcium channel Ca V 3.1, confer substantial risk for SCZ, implicating sleep-regulatory circuits in disease pathophysiology. Here, we first show that among individuals with SCZ, carriers...

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Literature Corpus work
6e29738f-d52c-5e50-b384-b499b3f9c492
DOI
10.64898/2026.02.04.703851
Open publication

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