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Article

Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort.

Brain : a journal of neurology - 3 Jun 2022

Baez-Nieto David, Allen Andrew, Akers-Campbell Seth, Yang Lingling, Budnik Nikita, Pupo Amaury, Shin Young-Cheul, Genovese Giulio, Liao Maofu, Pérez-Palma Eduardo, Heyne Henrike, Lal Dennis, Lipscombe Diane, Pan Jen Q

Abstract excerpt

CACNA1I is implicated in the susceptibility to schizophrenia by large-scale genetic association studies of single nucleotide polymorphisms. However, the channelopathy of CACNA1I in schizophrenia is unknown. CACNA1I encodes CaV3.3, a neuronal voltage-gated calcium channel that underlies a subtype of T-type current that is important for neuronal excitability in the thalamic reticular nucleus and other regions of...

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Identifiers

PMID: 34919654
DOI: 10.1093/brain/awab443
PMCID: PMC9166571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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