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Genetic correlation analysis identifies <i>TMEM106B, ACE</i>, and <i>ERC2</i> as genetic loci shared between Alzheimer’s disease and primary psychiatric disorders

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neuropsychiatric symptoms (NPS) occur in up to 85% of Alzheimer’s disease (AD) cases. Current treatments—repurposed from psychiatric disorders despite limited understanding of etiologic overlap—are often ineffective. <h4>Methods</h4> To characterize the genetic overlap between AD and major psychiatric disorders and identify shared molecular pathways we conducted genetic cor...

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Literature Corpus work: 7cf40c4f-d220-5528-9ce1-f6767c9d8955
DOI: 10.1101/2025.10.03.25336901

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