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Article

Shared genetic architecture between Alzheimer's disease and psychiatric disorders revealed by multi-trait genome-wide analyses.

BMC medical genomics - 28 Apr 2026

Zhang Huajun, Xie Liangzhuo, Meng Facai, Cui Jiangli, Ma Bo, Wang Yu, Zhang Kai, Miao Xingyu

Abstract excerpt

OBJECTIVE: Clarify the shared genetic architecture between Alzheimer’s disease (AD) and major psychiatric disorders. METHODS: We integrated large GWAS summary datasets derived predominantly from individuals of European ancestry for AD and eight psychiatric disorders; estimated genome-wide genetic correlations with LDSC/HDL; mapped local genetic correlations with SUPERGNOVA; ran pairwise Multi-trait analysis of...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 42050540
DOI: 10.1186/s12920-026-02354-1
PMCID: PMC13267596

Genes

ADAM10
P4HTM
RAB27B
APP
CCDC71
EP300
GPX1
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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