Article
Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026
Kumar Ajneesh, Ray Nicholas R, Kurup Jiji T, Rosario Pamela Del, Manoochehri Masood, Stein Colin, De Vito Alyssa N, Cholerton Brenna, Sweet Robert A, de Jager Phil L, Klein Hans-Ulrich, Cuccaro Michael L, Beecham Gary W, Huey Edward D, Reitz Christiane
Abstract excerpt
INTRODUCTION: Neuropsychiatric symptoms (NPSs) occur in up to 85% of Alzheimer's disease (AD) cases. Current treatments - repurposed from psychiatric disorders despite limited understanding of etiologic overlap - are often ineffective. METHODS: To characterize the genetic overlap between AD and major psychiatric disorders and identify shared molecular pathways, we conducted genetic correlation analyses between AD...
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