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Article

Shared genetics and causal association between plasma levels of SARS-CoV-2 entry receptor ACE2 and Alzheimer's disease.

CNS neuroscience & therapeutics - 1 Jul 2024

Zhang Yan, Xu Fang, Wang Tao, Han Zhifa, Shang Hong, Han Kevin, Zhu Ping, Gao Shan, Wang Xiaojie, Xue Yanli, Huang Chen, Chen Yan, Liu Guiyou

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the highest risk of COVID-19 infection, hospitalization, and mortality. However, it remains largely unclear about the link between AD and COVID-19 outcomes. ACE2 is an entry receptor for SARS-CoV-2. Circulating ACE2 is a novel biomarker of death and associated with COVID-19 outcomes. METHODS: Here, we explored the shared genetics and causal association between AD and plasma...

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Identifiers

PMID: 39056224
DOI: 10.1111/cns.14873
PMCID: PMC11273102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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