Article
Epigenetic gene expression noise and phenotypic diversification of clonal cell populations.
Differentiation; research in biological diversity - 1 Jan 2008
Neildez-Nguyen Thi My Anh, Parisot Aurélie, Vignal Céline, Rameau Philippe, Stockholm Daniel, Picot Julien, Allo Valérie, Le Bec Christine, Laplace Corinne, Paldi Andras
Abstract excerpt
Spontaneous emergence of phenotypic heterogeneity in cultures of genetically identical cells is a frequently observed phenomenon that provides a simple in vitro experimental system to model the problems of in vivo differentiation. In the present study, we have investigated whether stochastic variation of gene expression levels could contribute to phenotypic change in human cells. We have applied the two...
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